EFFECTS OF PAXHERBAL BITTERS ON URIC ACID AND KIDNEY FUNCTION IN MALE WISTAR RATS FED A HIGH FRUCTOSE DIET

ABSTRACT

Paxherbal Bitters' Effects on Uric Acid and Kidney Function in Male Wistar Rats Fed a High Fructose Diet. High fructose diets have been linked to an increased risk of developing hyperuricemia and renal disease. Paxherbal bitters, a traditional herbal treatment, is said to have medicinal characteristics that could help mitigate the harmful effects of high fructose diets on uric acid levels and renal function. The purpose of this study was to look at the effects of Paxherbal bitters on uric acid levels and kidney function in male Wistar rats on a high fructose diet.Male Wistar rats were randomly assigned to one of four groups. control (normal diet), high fructose (HF), Paxherbal bitters (PB), and high fructose plus Paxherbal bitters (HF+PB). For 28 days, the HF and HF+PB groups were fed a high fructose diet, while the PB and HF+PB groups were given Paxherbal bitters orally at a rate of X mg/kg/day. Biochemical assays were used to detect uric acid levels, while serum creatinine and blood urea nitrogen (BUN) values were used to assess kidney function. Kidney tissues were also histopathologically examined. The high fructose diet elevated uric acid levels in the HF group substantially more than in the control group (p 0.05). However, when compared to the HF group, the HF+PB group had a substantial drop in uric acid levels (p 0.05). Furthermore, supplementing with Paxherbal bitters reduced the high fructose-induced increase in serum creatinine and BUN levels, indicating enhanced kidney function. Paxherbal bitters reduced kidney damage caused by a high fructose diet, according to histopathological analysis.In male Wistar rats fed a high sugar diet, Paxherbal bitters supplementation successfully lowered uric acid levels and enhanced renal function. These findings imply that Paxherbal bitters may have therapeutic potential in reducing hyperuricemia and renal damage caused by high fructose diets. More research is needed to understand the underlying mechanisms and assess the long-term effects of Paxherbal bitters on human subject.