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ABSTRACT
Ficus exasperata is a terrestrial Afro-tropical shrub with ovate leaves that grows up to about 20 m tall and prefers evergreen and secondary forest habitats. It is popularly known as sandpaper leaf tree in Nigeria due to the rough surface of the leaves which is used industrially to smoothen furniture surfaces. A number of pharmacological activities have been attributed to different parts The aim of this study was to evaluate the effect of Ficus exasperata on colon cancer using rat. Standard biochemical method to analyzed the level of cholesterol, glycerides and low density lipoprotein. The result for low density lipoprotein obtained in this study showed that the highest LDL was from co treatment (Group 5) with value of 381.24±112.00b while the least LDL was obtained in normal control (group 1). There was a significance difference across the groups with P<0.05 significance confidence difference for the subsets or groups. The cholesterol evaluation in this study showed that normal control had the highest cholesterol value of 140.07±15.21b while co treatment (group4) had the lowest cholesterol value of 85.22±15.74a, this implies that the treatments reduced the cholesterol level in the experimented animal drastically. However there was a significant difference in p-value across the group with P<0.05 confidence level of anova. The triglyceride content was obtained highest in co treated samples (group 4) with value of 139.41±15.21a while the lowest was obtained in standard treatment (group 8). There was no significance difference across the group while obtaining glyceride content, meaning that values across the groups were significantly indifference using Duncan anova p-value of 0.05 confidence level. The lipids manipulation such as LDL, cholesterol and glyceride-raising agents may provide us novel strategy toward this malignant disease, which still warrant further investigations on basic research and preclinical trials.
