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ABSTRACT
Plants with pharmacological significance used therapeutically can be seen as medicinal. These significances are first identified then several experiments and investigation follows before they are accepted and used in making drugs. In the present study, the therapeutic significance ofF. exasperata was studied using its methanol extracts to treat and identity its effects on 1,2-DMH-induced colorectal cancer in male Wister rats. This was backed up by a series of experiments and statistical evaluation. The study centered on the anti-cancer effects of this extract on the rats and how it comparesto other staple anti-cancer drugs(5-fluorouracil). Four (4) different tests were carried out to test for the anti-cancerous significance ofF. exasperata, using hemoglobin count, hematocrit,serum creatinine and urea levels as biomarkers. Relative to the control rats, hemoglobin count significantly increased (p < 0.05) in all the groups except in Grp. 5 and Grp. 6, where the increase was not statistically significant (p > 0.05). The results suggests that both the extract and 1,2-DMH induced colon cancer significantly raises (p < 0.05) HBG count, while treatment with 5-fluorouracil (in Grp. 8) had was not as effective as the positive control (Grp. 2), co-treated #1 (Grp. 4) and post- treated (Grp. 8) rats (HBG count of Grp. 2, 4 and 7 > Grp. 8 at p < 0.05). This is in contrast to the results of Harzallahat al., (2022), that conveys colorectal cancer reduces HBG 55 count via gastrointestinal bleeding. Taiebet al., (2022), found significantly lower HBG count (p < 0.05) brought by 5-fluorouracil treated rats than in rats treated with a biherbal extract containingF. exasperata.
