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ABSTRACT
The effect of sub-chronic administration of methanol leaf extract of Anthiocleista grandiflora on sperm parameters and testosterone in male Wister rats was evaluated for 28 days. Adult male Wister rats were randomly divided into four groups of five rats each. Group 1 received 10 ml/Kg/day of distilled water and served as the control, while groups 2, 3 and 4 received 200 mg/kg/day, 400 mg/kg/day and 800 mg/kg/day of the extract daily for 28 days by oral gavage. Sperm cells were collected from the vas deferens of the sacrificed male rats for the determination of sperm motility, sperm count and sperm morphology while blood samples were obtained via the abdominal aorta for hormonal assay. Testes weight was also recorded. Data were analyzed using One-way ANOVA and P<0.05 was recognized as significant. The result from these studies showed that the extract did not significantly alter (P>0.05) sperm count, motility and the testosterone parameters, but there was an increase in the percentage of formed sperm when compared with the control group. Also, no significant changes were observed in the weight of the testes. In conclusion, the result suggests that the oral treatment with 200-800 mg/Kg/day of the methanol extract of the seed of Anthiocleista grandiflora did not produce any toxicity to the reproductive functions of the male rat.
