You have no items in your shopping cart.
ABSTRACT
The Tetrapleura tetraptera plant has been reported to show a variety of therapeutic capabilities ranging from anticonvulsant properties to antimicrobial, anti-inflammatory, analgesic, post-partum contraction prevention in nursing mother, malaria, flatulence and jaundice in babies. The potent phytochemicals present in the fruit has made it a choice medicinal plant in many regions in Nigeria. This project aims to investigate the potent therapeutic effects of the hydroethanolic extract of Tetrapleura tetraptera on liver function parameters in ccl4-induced toxicity in the liver. The study was carried out using thirty rats were divided into five groups. Group 1 was labelled the normal, Group 2 served as a negative control, Group 3 served as a positive control, Group 4 was treated with 250mg/kg of the hydroethanolic extract of the plant and Group 5, was treated with 500mg/kg of the extract. The toxicant, 5ml of ccl4 was administered intraperitoneally with 5ml of olive oil as per body weight. The liver function parameters analyzed were Total protein, Total and Conjugate bilirubin, Albumin and Globulin and the results showed increased concentration in Bilirubin and Total protein levels (p<0.05) but no significant changes in the Albumin and Globulin levels when compared to the control groups. These findings suggest the potential therapeutic use of Tetrapleura tetraptera in protecting the liver from toxic injury and warrants further investigations into its underlying mechanisms of action.
