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ABSTRACT
The consumption of palm oil is widespread, particularly in Nigeria, where it serves as a major source of dietary fat. However, concerns regarding the effects of storage on its biochemical properties and potential health implications necessitate further investigation. This study examines the effects of fresh and stored palm oil on serum creatinine levels and kidney histopathology in Wistar rats. Thirty-six male Wistar rats were divided into six groups and administered fresh or stored palm oil with varying free fatty acid (FFA) concentrations for four weeks. Serum creatinine levels were assessed using spectrophotometric methods, and histopathological examination of kidney tissues was conducted. The results indicate a significant decrease (p<0.05) in serum creatinine levels with increasing FFA concentrations, suggesting potential renal impairment. Histopathological analysis revealed structural changes in the kidney tissues of rats exposed to stored palm oil, including glomerular atrophy and tubular degeneration. These findings highlight the nephrotoxic effects of oxidized palm oil and suggest that prolonged storage may compromise renal function. Further studies are recommended to evaluate the underlying mechanisms and long-term health implications of stored palm oil consumption.
