ABSTRACT
Alzheimer's disease (AD) stands as a formidable challenge in modern medicine, with its progressive neurodegenerative nature posing significant hurdles in both understanding and treatment. Bryophyllum pinnatum is a perennial herb that grows extensively in tropical and equatorial regions of Africa, tropical America, India, China, and Australia. The aim of the study is to investigate the Effects of bryophyllum pinnatum on learning and memory in Alzheimer's disease animal model using cognitive assessment tools. The Twenty (25) male wistar rats were divided into five (5) groups. (groups 1, 2, 3, 4 & 5) with 5 animals in each group, group 2, 3, 4 and 5 served as the test groups, while group 1 served as the test control. Group 2, 3, 4, and 5 animals were administered calculated level of Aluminium chloride for 25 days, Saline was administered for three (3) days after administration of Aluminium chloride and two (2) weeks of treatment with aqueous of bryophyllum pinnatum extract. Groups are divided into two; Group 1 as Control comprised rats feed with regular water while test group as Group 2 (Alzheimer`s disease not treated with Bryophyllum pinnatum). Group 3 (Alzheimer`s disease and treated with bryophyllum pinnatum). Group 4 (Alzheimer`s disease treated with cognitol and bryophyllum pinnatum). Group 5 (Alzheimer`s disease treated with bryophyllum pinnatum and vit. D). With five rats in a group. Aluminium chloride was administered to group 2,3,4 and 5 for a period of twenty-five (25) days after which a stock solution was prepared for administration, 0.5g of Aluminium chloride in 100ml of water. The dosage of Aluminium chloride is 175mg/kg. thereafter, saline was administered for 3 days. During the period of challenged the tested group are being treated with bryophyllum pinnatum extract. Thereafter the rats behaviors were tested using cognition assessment tools. The statistical analysis was performed in graph. All statistical analysis was carried out using microsoft excel version 2021. The data obtained from all the groups was presented as Mean ± S.E.M (Standard Error of Mean), (n=5) in each group and analysed for statistical significance by using one-way Analysis of Variance (ANOVA). Values was considered significant at P < 0.05. In conclusion, there is potential benefit of bryophyllum pinnatum in improving cognitive function in rats models of Alzheimer`s disease showing promising result which suggest that bryophyllum pinnatum may have a positive impact on learning and memory.
