ABSTRACT

A rapid decline in kidney function brought on by the harmful effects of drugs and substances is known as nephrotoxicity. Inhalation, ingestion, and skin contact are the principal routes of potential human exposure to CCl4. SPONDIAS MOMBIN has antimicrobial, antibacterial, antifungal, and antiviral activities. The aim of this research is to investigate the effect of aqueous SPONDIAS MOMBIN leaf extract on carbon tetrachloride-induced nephrotoxicity in adult Wistar rats. Twenty adult Wistar rats weighing between 130g and 180g were used for this experiment with five rats being in each group. Group A was the control. Group B was administered with carbon tetrachloride only (1ml/kg). Group C was administered with SPONDIAS MOMBIN low dose extract of 250mg/kg and carbon tetrachloride (1ml/kg). Group D was administered with SPONDIAS MOMBIN high dose extract of 500mg/kg and carbon tetrachloride (1ml/kg). The animals were allowed to acclimatize for 14 days before commencement of experiment. The experiment took place for 14 days. And on day 15, the animals were euthanized under chloroform anaesthesia. The kidneys were harvested for histological procedures and blood samples were taken for kidney function test. The histological observation showed that CCL4 induced kidney damage. The pretreatment with SPONDIAS MOMBIN L was able to protect the kidneys from the nephrotoxic effects of CCL4.