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ABSTRACT
Datura Stramonium a member of the Solanacea family is a plant widely spread across tropical and temperate regions, and known for its pharmacological and toxicological properties. Extracts from D.stramonium have demonstrated lipidemic effect, sedative and psychoactive effects, anti-inflammatory, antimicrobial and anticholinergic effects. This study was aimed at evaluating the effects of varied concentrations D.stramonium aqueous leaf extract on Lipid profile of Drosophila melanogaster. A total of 160 flies were divided into four groups comprising of control group, 2000mg/kg group, 4000mg/kg group and 8000mg/kg group. The lipid parameters which are High-density lipoprotein (HDL): Low-density lipoprotein (LDL): Total Cholesterol (TC): and Triglycerides (TG): were analyzed and determined. The lipid profile analysis revealed significant increase (p<0.001) in HDL, LDL and TC levels across all treatment groups when compared to their control groups. The experimental group that received 4000mg/kg of D.stramonium had significantly higher (p<0.05) HDL levels compared to the groups administered 2000mg/kg and 8000mg/kg of D.stramonium leaf extract. The 4000mg/kg group also showed a significant increase (p<0.01) in LDL levels when compared to the 2000mg/kg group and also a significant increase (p<0.005) in LDL levels when compared to the 8000mg/kg group. As concerning the TC levels the groups administered 4000mg/kg and 8000mg/kg of D.stramonium showed significantly higher (p<0.05) TC levels compared to the 2000mg/kg group. Finally only the group administered 8000mg/kg (19.33±0.577) of D.stramonium showed significantly higher (p<0.01) TG levels when compared to the control (15.33±0.577): there was no significant difference (p>0.05) in TG levels among the 2000mg/kg and 4000mg/kg group when compared with the control. In conclusion, these results showed that D.stramonium has effects on the various lipid indices and these effects are dose-dependent.
