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ABSTRACT
Methoxyacetic acids (MAA), the active biological oxidation product of the industrial solvent ethylene glycol monomethyl ether (EGME), is known to cause acute toxicity in several species including humans. Biochemical and histological analysis were conducted to determine the effect of two weeks exposure of methoxyacetic acid on the liver of male rats. Nineteen male albino wistar rats weighing 194 ± 28.19 g were divided into two groups of 10 and 9 respectively and were fed with rat chow for two weeks along with water ad libitum. Biochemical parameters of liver function determined include direct and total bilirubin, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) activities. Change in weight and relative liver weight after two weeks was also determined. Results do not show significant increase in body weight and relative liver weight, total and direct bilirubin, ALT, AST, as well as ALP when compared with the control. Histopathological result showed severe zonal necrosis and periportal infiltrationof inflammatory cells in the liver after one weekbut a reduction in the severity in zonal necrosis and inflammatory cells after two weeks. These resultsindicate that a single dose administration of MAA (450 mg/kg) caused liver damage on oral exposure after one week but the liver was able to ameliorate the toxic effects after two weeks.
