EFFECT OF THE PALM OIL ADDITIVES SUDAN III AND SUDAN IV ON THE BODY WEIGHT, WEIGHT OF LIVER, GST AND GSH IN LIVER OF WISTAR RATS

ABSTRACT

Unauthorized food additives Sudan III and Sudan IV, which are found in palm oil, are known to be hazardous. Their effects on body weight, liver weight, and antioxidant enzyme levels in the liver of Wistar rats, including glutathione S-transferase (GST) and glutathione (GSH), were examined in a study. Three weeks were allotted to the trial. First week was for acclimatization; second week was daily administration of Sudan III & IV. For this investigation, a total of 48 male albino rats were utilized, and each animal received an equal amount of food and water. For study purpose, they were divided into eight (8) groups, each with six (6) animals. The study's findings show that Wistar rats' body weight was significantly affected by exposure to greater dosages of Sudan III (50 mg/kg) and Sudan IV (10 mg/kg and 50 mg/kg) dyes. The groups exposed to Sudan IV dyes showed considerably reduced mean GST activity in the liver than the other groups, as per the results. The findings showed that, in comparison to the control, exposure to Sudan IV dye at a lower dose (10 mg/kg) considerably raised the GSH levels in the liver. as well as additional therapy groups. The study's findings showed significant variations in liver weights among the various treatment groups, which may have resulted from differences in liver metabolism or hepatic injury brought on by exposure to Sudan dyes. The aforementioned findings underscore the significance of tackling the problem of unapproved food additives and their possible health hazards.