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ABSTRACT
Aluminium chloride is an industrial chemical used in the production of various plastic materials. It is associated with immunological and neurological disorders.
Aluminum has been used to model neurotoxicity and AD-like neurodegeneration in various animal models. In D. melanogaster, Al toxicity has been associated with impaired locomotor performance, learning and memory, as well as redox imbalance (Ogunsuyiet al., 2020) which are synonymous to neurodegeneration. One of the key hypotheses of Al toxicity is increase MDA. This agrees with other studies that reveal that Al can induce elevated MDA. (El-Demerdash et al., 2010), found that treatment with aluminum chloride led to increased MDA levels in the liver and brain of mice. MDA is a strong biomarker of oxidative stress. Naringenin is an important antioxidant and inflammatory substance. The number of hydroxyl substitutions of naringenin can donate hydrogen to ROS, allowing acquisition of stable structure, thus enabling scavenging of these free Radicals (Shen et al., 2004). Van Acker et al. (2000) reported that aglycone of naringenin, naringin can assume the role of alpha-tocopherol as achain-breaking antioxidant in liver microsomal membrane. In addition to this a study, published in the journal "Food and Chemical Toxicology" in 2013, found that treatment with naringenin increased the activity of GST in the liver and brain of mice. GST is an antioxidant enzyme. Drosophila melanogaster flies (Harwich Strain) of both genders divided into the flies were divided into six groups with each vials containing 50 flies. Group C: Control flies fed on 10g of basal diet.
