EFFECT OF MEYHANOLIC EXTRACT OF THE LEAVES OF Phyllanthus amarus Wild (Euphobiaceae)

ABSTRACT

The use of the plant leaves of Phyllanthus amarus in the treatment of diseases condition has been a common practice among humans for many years. Few of the many effects of phyllanthus amarus are: Antiseptic, Antiviral, antipyretic, jaundice, urogenital disease and erectile dysfunction, wound healing and ulcers. In this work, the methanolic extract of the leave of phyllanthus amarus was evaluated for the motility effects in mice small intestine using the charcoal meal test. A plant material was collected around the premises of UNIBEN, between the month October and November 2021. A sample of the leaf was identified in the department of pharmacognosy. The leaves were air dried for seven (7) days. The dried leaves were reduced to fine powdered using a Viking Joncod Electric Milling Machine. The powdered plant material (500g) was extracted using a soxhlet apparatus and give a yield of about 17%. The extract was concentrated to a solid mass. A specific weight of the extract was dissolved in an appropriate volume of distilled water to obtain a stock solution of desired concentration from which calculated doses were administered to the animals during the various experimental procedures.