EFFECT OF METHANOL EXTRACT OF GEOPHILA OBVALLATA ON SERUM TRIGLYCERIDE LEVELS OF CCl4 TREATED RATS

ABSTRACT

Geophila obvallata leaves, stems and roots are used medicinally to treat various kinds of disease such as abdominal troubles, hypertension, tooth ache, jaundice, diabetes, stroke and cardiovascular diseases in Nigeria. Liver diseases are worldwide problem. Medicinal plants are increasingly utilized to treat a wide variety of diseases; liver disorder inclusive. This study investigated the hepatoprotective activity of pre-treated with the methanolic leaf extract of Geophilia obvallata ( GOE) against CCl₄-induced hepatotoxicity in Wistar rats. A total of 30 Wistar rats were divided into six groups I – VI of five rats each. Group I was the control, while groups II-IV were treated groups. Groups III, IV and V were orally administered GOE at doses of 50mg/kg, 100mg/kg and 150mg/kg respectively. Group VI were administered GOE only (100mg/kg) and group II was administered CCl₄ only. Treatment lasted for two weeks. Hepatotoxicity was induced in the treatment group’s animal by administering a single dose of CCl₄.