ABSTRACT
To determine the effect of low does paxherbal bitters on fasting blood glucose and lipid profile parameters, 20 male albino rats in groups of 4 (5 each with an average of 200g) were given basal feed with distilled water, a combined high salt diet with distilled water, and a combined high salt diet with low dose pax herbal bitters respectively for a period of 6 weeks. Their weights were recorded at the end of each week, their fasting blood glucose and lipid profile were determined at the end of the 6 weeks. The first cage was fed with basal feed and distilled water, the second was fed with a combined high fat and salt diet and water, the third was fed with a combined high fat and salt diet and Artovastatin and Lisinopril while the last was fed with a combined high fat and salt diet and low dose pax herbal bitters.
Total cholesterol showed a significant increase (p <0.05) in rats fed a combined high fat and salt diet with low dose pax herbal bitters. Blood HDL-cholesterol showed a significant increase (p<0.05) in rats fed a combined high fat and salt diet. Triglyceride showed a significant change (p<0.05) in rats fed a combined high fat and salt diet with low dose pax herbal bitters. VLDL cholesterol showed a significant change (p<0.05) in rats fed a combined high salt and fat diet with low dose pax herbal bitters.
LDL cholesterol showed a significant change (p<0.05) in rats fed a combined high fat and salt diet with low dose pax herbal bitters. There was a significant change (p<0.05) in the fasting glucose level of rats fed with a combined high fat and salt diet.
Glucose and lipid profile tests were carried out on the samples drawn which showed that low dose pax herbal bitters can serve as a preventive therapy for hyperglycemia and hypercholesterolemia and other risk related cardiovascular diseases.
