You have no items in your shopping cart.
ABSTRACT
In this study, the effect of ingested Pinkwater BioSolve and crude oil on Total Protein level, Lipid peroxidation and Antioxidants status of the heart of Albino Wister rats was investigated. Thirty (30) Wister rats weighing between 170-180g were sorted into ten (10) groups of three (3) animals each. Group 1 was orally administered soluble crude portion of crude oil. Groups 2,3 and 4 were orally administered BioSolve at different concentrations, while groups 5 and 6 were orally administered BioSolve remediated soil water. Whereas group 7,8 and 9 were orally administered soluble crude portion and BioSolve at different concentrations. Group 10 was the control group which was left untreated. At the end of the study, the rats were sacrificed and the heart harvested for biochemical analysis. The results showed a dose-dependent significant (P < 0.05) decrease in plasma glucose and a corresponding significant (P < 0.05) increase in the level of lipid peroxidation in the heart of all groups when compared to the control group. There was a significant (P>0.05) increases in the level of Total protein for all groups when compared with control. However, the result for the antioxidant status of the heart showed a non-significant change in the SOD level. Whereas there was a significant (P<0.05) decrease in the levels of CAT and GPx when crude oil and BioSolve were orally administered separately. While there was a significant(P>0.05) increase in the levels of CAT and GPx when crude oil and BioSolve were orally administered in combination. These observations seem to indicate that consumption of feed contaminated with petroleum and Biosolve hydrocarbons could induce a hypoglycemic state as well as impose oxidative stress in the heart of rats through the enhanced lipid peroxidation and lowered activity of CAT and GPx. Also BioSolve and Crude oil in combination seem to be more toxic than each acting alone.
