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ABSTRACT
The liver plays an important role in detoxifying substances. Liver-related diseases are increasing due to shifts in dietary habits and rise in drug usage. Toxic liver damage and other liver diseases remain significant global health concerns. Carbon tetrachloride is a recognized hepatotoxic substance that can induce liver damages. Certain plants are used as herbal remedies for liverrelated ailments. Chasmanthera dependens, a flowering plant from the Menispermaceae family, is contains phytochemicals with anti-hepatotoxic properties. This study aims to assess the effect of Chasmanthera dependens extract on oxidative stress in wistar rats CCl4-induced toxicity. A total of 25 male wistar rats were employed in this experiment, divided into five groups: Group 1 (normal control), Group 2 (negative control, no treatment), Group 3 (positive control, treated with silymarin), Group 4 (treated with hydroethanol extract of Chasmanthera dependens at 250mg/kg) and Group 5 (treated with hydroethanol extract of Chasmanthera dependens at 500mg/kg). Through systematic experimentation and analysis, this research investigates the hepatoprotective properties of the hydroethanol extract of Chasmanthera dependens and its potential to alleviate CCl4-induced liver toxicity. It directly focuses on oxidative stress parameters. The outcome showed that the hydroethanol extract of Chasmanthera dependens was able to increase the activity of antioxidants against oxidative stress significantly (p<0.005) as the standard drug - silymarin, except for MDA, compared to the negative control group.
