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ABSTRACT
The relationship between exercise and renal function is a rather controversial topic. Cisplatin is a chemotherapy drugs used in the treatment of cancers with nephrotoxicity as one of its major side effects. This study is aimed at investigating the overall effect of exercise as a preventive as well treatment option in the management of cisplatin-induced acute kidney injury (AKI). 25 male albino Wistar rats were used for this study. After a two weeks acclimatization period, the rats were randomly divided into five groups (n=5): Group 1 (Control), Group 2 (Ex), Group 3 (cisplatininduced), Group 4 (Cp+Ex), Group 5 (Ex+Cp). The animals in group 3, 4 and 5 were induced with AKI using intraperitoneal administration 3.0mg/kg Cisplatin which was administered for 3 days with a daily interval between each dose. The rats in group 2, 4 and 5 were subjected to aerobic exercise as a moderate regular exercise on a treadmill machine at the speed of 3km/h for 5 minutes at 0% inclination for 5 days/week for 3 week. After the research period animals were sacrificed and blood, urine and kidney samples were obtained for laboratory analysis. urine and serum electrolyte, creatinine (Cr) and urea concentrations as well as urine albumin and serum cystatin C (Cys-C) concentration were analyzed. Results were statistically analyzed using the Graph pad prism statistical software version 8.0.1, comparison within groups was done using one-way ANOVA and comparison between groups was done using the Duncan’s Multiple Range test. The results were presented as Mean ±SEM and P-value of less than 0.05 (˂0.05) was considered statistically significant. The result showed no statistically significant difference in group 2 (Ex) when compared to control. In group 3 (cisplatin-induced) group there was notable structural damage with histological focal tubular necrosis and vascular stenosis. There was also a significant increase in serum Cr, urea and blood urea nitrogen (BUN) levels.
