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ABSTRACT
The ability of the etahnolic stem bark extract of M. lucida to decrease the blood glucose of hyperglycemic rats towards normal confirms its antidiabetic activity. The stem bark extract of M. lucida also inhibited diabetic complications by preventing an alteration in plasma concentration of AST, ALT and ALP activities. M. lucida extracts were able to induce changes in ALT and AST activity in experimental animals showing their protective potentials. The ethanolic stem bark extract of M. lucida possesses good antioxidant potentials by inhibiting collapse of antioxidant defense induced by streptozotocin. The bioactive substances identified in this plant material may account for its medicinal and antioxidant properties. The ability of M. lucida stem bark extract to prevent the alteration of antioxidant status explains their protective role. The ability of the plant extract to stimulate gene expression on investigation was adjudged by observing statistically significant modulation (P≤0.05) of the genes in study after the plant extract on investigation intervention. For the transcriptional profiling dataset, a tukey post hoc test was conducted to assess the relative abundance of ACC, ACL, SCD genes after compound on investigation intervention of which a significant upregultion (@ P≤0.05) was observed.
