ABSTRACT
Background: Tetrapleura tetraptera (Fabaceae) is frequently used in Tropical African traditional medicine for the management and/or control of an array of human ailments, including arthritis and other inflammatory conditions.Uterine Fibroids are abnormal growths that develop in or on a woman’s uterus. In some cases, these tumors become quite large and can lead to severe abdominal pain and heavy periods.Generally, medicinal plants play a key role in herbal medicine either alone or in combination with other healing strategies.
Aim:The aim is to evaluate the anti-fibroid property of the ethanol extract of Tetrpleura tetraptera podon MSG-induced uterine leiomyoma in wistar rat using curative method.
Objective:This study assessed the ability of the extract to shrink fibroid through curative method
Methods: The pods of Tetrapleura tetraptera were dried, pulverized by milling, extracted using soxhlet apparatus and concentrated using a rotary evaporator. The rats were divided into five groups (A, B, C, D, and E), of five rats each. Group A (control) received only food and water. In an effort to stimulate the formation of uterine hyperplasia, groups B, C, D, and E were given 800 mg/kg of MSG for 30 days. Then, groups C, D, and E were given 100, 200, and 400 mg/kg of T. tetraptera pod extract, respectively, once daily for another 30 days. All administration was done by the means of oral gavage. The animals were sacrificed, blood samples were collected and assessed.
Result: There was significant increase in the levels of estrogen (estradiol) in the MSG treated rats relative to the groups treated with the extract of T. tetraptera. The extract of at various doses also decreased total cholesterol, relative to the MSG group. There was no significant difference in the protein levels when different concentrations groups were compared to MSG group (p>0.05).The epithelial cells and lamina propria of rats treated with the extract showed a decrease in the distortions that was caused by MSG.
Conclusion: Extract of Tetrapleura tatraptera pod may contain bioactive constituents useful in the management of fibroid as it reduces serum hormone levels which play roles in the etiology of uterine fibroid.
