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ABSTRACT
The liver is an organ that helps to remove toxic substances from the body . One of the most lethal diseases in the world, liver-related diseases are currently increasing because of changes in food habits and increased use of certain drugs. It is possible to harm and the liver with carbon tetrachloride, a know hepatotoxic agent. A damaged liver can cause changes or disruptions in the lipid profile. Certain plant species have ling been used as herbs to treat liver-related ailments. A member of the Menispermaceace family, Chasmanthera dependens is a flowering plant. Certain phytochemicals that the plant is thought to contain have antihepatotoxic qualities. The aim of this study is to evaluate the effects of C.dependens root extract on lipid profile in CCl4 induced toxicity in wistar rats. A total of 25 male Wister rats were used for this experiment. They were grouped into 5 groups; Group 1 (normal control), Group 2 (negative control group, no treatment), Group 3 (positive control, silymarin treatment), Group 4 (ethanol extract of C.dependens treated group, 250mg/kg), Group 5 (ethanol extract of C.dependens treated group, 500mg/kg). The ethanol extract of C.dependens is investigated for its hepatoprotective qualities and its capacity to lessen CCl4 induced liver toxicity through systemic experimentation and analysis. The research focuses on lipid profile parameters like total cholesterol, triglycerides, low density lipoprotein cholesterol, and high density lipoprotein cholesterol.It was concluded that absolute ethanol extract of Chasmanthera dependens in both doses shows no significant effect (P > 0.05 ) on TC, HDL, and LDL serum level but there was a significant effect (P < 0.05 ) of the doses on serum triglycerides level. So, for some changes involving specific lipid profile parameters, C.dependens ethanol extract can act as a cure.
