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ABSTRACT
The liver is responsible for the metabolism and detoxification of the most of components that enter the body. Carbon tetrachloride (CCl4) is a highly toxic chemical agent, the most famous drug used to induce liver damage experimentally. Entandrophragma utile has been deeply studied for its special properties because of its higher hepatoprotective. The present study was designed to examine the preventive effects of Entandrophragma utile against the toxic effects of acute exposure to carbon tetrachloride (CCl4) on the liver tissue of rats. Administration of a single dose of CCl4 caused liver toxicity taking into consideration biomolecules like Total protein, Total Bilirubin, Direct Bilirubin, and Indirect Bilirubin. A total of 16 wistar rats were divided randomly into 4 groups comprising 4 rats in each group, G1 The first group is normal control, G2 was the Negative control intoxicated with CCl4 and untreated, (G3) Rats was the positive control intoxicated with CCL4 and treated with a standard drugs( Silymarine), and (G4) Rats fed which were also injected with CCl4 and treated with 200mg of crude ethanoic plant extract.l( Entandrophragma utile). A significant (P < 0.05) difference in Total protein, Total Bilirubin, Direct Bilirubin and indirect bilirubin activities was observed in the CCl4- treated rats compared with those of the control rats, respectively. Based on this study, Entandrophragma utile have a protective effect against CCL4-Induced Hepatotoxicity.
