EFFECT OF CONSUMPTION OF DIET MIXED WITH RED MEAT TENDERED WITH POTASH ON THE LIVER OF WISTAR RAT.

ABSTRACT

This study was aimed at investigating scientifically the effect of consumption of meat boiled with potash on the liver marker enzymes of wistar rat. Twenty-five (25) adult male albino wistar rats divided into five (5) groups were used for this study. Group one served as the control and the rats were fed with water and normal feed (grower’s mash), Group two served as the negative control (uncontaminated group) and the rats were fed with normal feed thoroughly mixed with meat not boiled with potash and water, Group three, four and five were the test group and the rats were fed with normal grower's mash thoroughly mixed with 10%, 20%, 30% of red meat boiled with potash, respectively for a period of twenty-eight (28) days. Biochemical indices of liver function determined include serum total protein, albumin, aspartate aminotransferases (AST), alanine aminotransferases (ALT), and alkaline phosphatase (ALP) activities. The results were statistically analyzed and a p- value greater than 0.05 was considered statistically insignificant. The concentration of albumin decreased in group three, four and five when compared to the control group. The concentration of total protein was decreased in group three, four and five when compared with the control. Also, ALT and AST activities increased in group three, four and five when compared with the control. The activities of ALP increased in group three, four and five when compared with the control. The result showed that consumption of meat boiled with potash is detrimental to the liver of wistar rat as it may lead to hepatocellular damage and altered or impaired liver function.