EFFECT OF CHANNELING AGENT ON THE RELEASE PROFILE OF DICLOFENAC TABLET FORMULATED USING IRVINGIA GABONESIS AS GUM

ABSTRACT

Objective: The aim of the study was to investigate the effect of channeling agents (mannitol) on the release profiles of diclofenac tablets formulated using Irvingia gabonensis gum.

Method: Diclofenac tablets were formed using the wet granulation technique and Irvingia gabonesis gum (10%w/w) was used as the binder. Channeling agents (mannitol) at varying concentrations alongside talc (1%w/w) were incorporated into the diclofenac granules before compression at a compression pressure of 28 N/m².

Results: The granules were evaluated for micromeritic properties such as bulk and tapped densities, angle of repose, while crushing strength, friability and in-vitro dissolution studies were performed for the formulated tablet. All granules were free flowing with angle of repose ≥30^o. The release data were subject to different release kinetics and their release mechanism was studied. From the result, M4 (with 200mg of mannitol) had the dissolution rate of 22.95%/h^-1 which was higher than M0 (no mannitol) of 15.35%/h^-1 Indicating that the dissolution rate increased with the concentration of the channeling agents and the mechanism of drug release from these formulations followed the first-order kinetics.

Conclusion: The presence of channeling agents influenced the release of drugs from the matrix system studied. Therefore, appropriate channeling agents can be used to enhance and modulate the release of drugs from such systems