You have no items in your shopping cart.
ABSTRACT
Blood coagulation, or clotting, is a complex biological process in which blood changes from a liquid to a gel-like state to prevent excessive bleeding after injury. Calcium carbide (CaC2) is a chemical which is now commonly being used for the artificial ripening of fruits has been reported to have effects on blood hematological parameters. Prothrombin time (PT) and Activated partial Thromboplastin Time (APTT) are two of many blood tests to investigate the effect of calcium carbide (CaC2) on prothrombin time (PT) and activated partial thromboplastin time (APTT) of male wistar rats. A total of 70 male wistar rats were used in this study. They were grouped into four (4) groups comprising the control group, and three (3) experimental groups: Low dose, Medium dose and High dose. The duration of this experiment was six (6) weeks: Two (2) weeks for acclimatization and 4weeks for administration. At the end of the administrations, blood samples were collected via cardiac puncture with the aid of a syringe for sample analysis. Data obtained were analyzed using graph pad prism version 8.1. ANOVA was used to compare the mean. A P value of P <0.05 was taken as statistically significant. Hence, the results obtained from this study showed that calcium carbide had effects on PT extrinsic and common pathways and aPTT intrinsic pathway when administered in male wistar rats.
