ABSTRACT

The study investigates the impact of the aqueous-methanol extract of Azanza garckeana on histological parameters in Wistar albino rats. Azanza garckeana, commonly known as African wild loquat, is recognized for its medicinal properties. The project aims to explore its potential effects on the microscopic structure of tissues in rats, focusing on organs such as the liver, kidney, and heart. The research methodology involves the extraction of bioactive compounds from Azanza garckeana using a mixture of water and methanol, followed by administration to the experimental group of rats. Histological analyses are conducted to assess any alterations in tissue architecture, cellular morphology, and pathological changes compared to the control group. Histopathological findings from this study revealed no alteration in the organs; liver, kidney, heart, colon and testis of male Wistar albino rats administered aqueous-methanol root extract of Azanza garckeana. These findings indicate that the plant extract did not compromise the cellular integrity nor inflict damage to these organs. The findings provide insights into the potential therapeutic or adverse effects of Azanza garckeana extract on organ health, contributing to our understanding of its pharmacological properties. This investigation holds significance in the field of biochemistry by elucidating the biological mechanisms underlying the effects of natural products on histological parameters, which could pave the way for further exploration of Azanza garckeana as a potential source of novel pharmaceutical agents.