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ABSTRACT
Moringa oleifera is a very is a nutritive plant that is perfect for treating malnutrition in underdeveloped nations due to its nutritional benefits. It contributes significantly to the diet of humans and is a good source of protein, carbohydrates, vitamins, and minerals. The leaves of Moringa oleifera contain phytochemicals that may impact one's health. Despite being scarce, certain research studies have described the nutritional and therapeutic uses of the leaves of Moringa oleifera. This study was aimed at determining the effect of administration of feed formulated from Moringa oleifera leaves on some haematological Parameters and oxidative stress markers of Gasoline vapour stress induced albino wistar rats. A total of fifty-eight (58) albino wistar rats were used for this study. Eighteen wistar rats were grouped into six (6), each group consisting of three (3) rats for toxicity test while Forty (40) experimental rats were divided into four groups, each consisting of ten (10) rats. The experimental groups were control; stressed; stressed with administration of low dose (250mg/kg b.w) aqueous leaf extract of Moringa oleifera; and stressed with administration of High dose (1000mg/kg b.w) aqueous leaf extract of Moringa oleifera. The rats were stressed by placing gasoline-soaked cotton wool in the rat cages of the test groups for 1 hour each day for twenty-eight (28) consecutive days. At day twenty-eight (28), blood samples were collected from the rats by cardiac puncture and placed in ethylene diamine tetra acetic acid (EDTA) containers for full blood count estimation and lithium heparin containers for oxidative stress analysis. Automated ERMA autoanalyzer PCE-210 was used to analyze the haematological parameters while Enzyme linked immunosorbent assay (ELISA) was used to analyze Malondialdehyde (MDA), Catalase (CAT) and Superoxide dismutase (SOD) for oxidative stress. The experiment's findings revealed that exposure of animals to Gasoline vapour alone significantly (p < 0.05) increased malonaldehyde (MDA) levels and decreased superoxide dismutase (SOD) level and catalase (CAT) levels. There was a significant decrease in the haemoglobin and haematocrit values (p=0.027 and 0.008 respectively) in the stressed groups when compared to the corresponding values in the control group. In conclusion, the result of this study shows that Moringa oleifera leaves have an effect on gasoline vapour stress induced albino wistar rats and some haematological parameters.
