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ABSTRACT
Medicinal plants are employed in various parts of the world in the treatment of large variety of diseases, including blood-related disorders. However, a number of herbal preparations have been reported to cause variations in clotting time, this is mainly by disruption of the coagulation cascade.This study is aimed at determining the possible haemostatic effect of aqueous extract of Justicia secunda leaveson haemostatic parameters of phenylhydrazine(PHZ) treated albino wistar rats.. Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT) and platelets count were carried out on the experimental wistar rats. Thirty (30) wistar rats were used for this study. The rats were randomly grouped into five (5) groups of six (6) rats each – Group A ( Control) was given feed and water only, Group B (Anaemic group), Group C (190mg/kg bw of Justica secunda), Group D (380mg/kg bw of Justicia secunda), Group E (200mg/kg bw of Ferrous sulphate). Phenylhydrazine (PHZ) was administered at a dose of 10mg/kg bw to the experimental groups B, C, D and E to induce anaemia. After 28 days of administering Justicia secunda extracts to groups B, C and D, the rats were humanely sacrificed and blood samples were collected for laboratory analysis. From the result of the experiment, it was observed that the platelets counts of the groups B, C and D that was administered Justicia secunda extract had no significant difference (p > 0.05) compared to the control group A, but there was a significant increase (p<0.05) between group C which was administered low dose of Justicia secunda extract and group E which was administered a known hematinic (Ferrous sulphate). While the PT and APTT of groups B, C and D were significantly higher (P<0.05) compared to the control group A. Also, PT and APTT were significantly lower (P<0.05) in group C (190mg/kg bw of Justicia secunda extract) compared to group E (Ferrous sulphate). In conclusion, Justicia secunda extract has no effect on the platlets count of adult albino wistar rats but has a considerable impact on the PT and APTT of adult albino wistar rats.
