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ABSTRACT
Diabetes mellitus is a metabolic disorder of the endocrine system, this disease is affecting millions of people all over the world and it is becoming a serious threat to mankind. The present study investigated the antidiabetic activity of Nigel/a sativa in streptozotocin induced diabetic rats through some molecular markers like GLUT2, PPAR and PFK. Nigella sativa oil was extracted by dissolving the blended seed in ethanol and later filtered and the filtrate was freeze- dried. Twenty four (24) male wistar rats were assigned into different groups after being acclimatized for two weeks; group one (1) being normal control, while group 2-4 were induced with diabetes using streptozotocin after being fed for 28 days. Group two is the diabetic control, group 3 was treated with metformin, and group 4 was treated with the plant extract. Animals were sacrificed on the 28th day, tissues excised and GLUT2, PPAR and PFK gene expressions were assessed. The result of this study revealed that PFK, PPAR and GLUT 2 gene were expressed most in normal control group whereas diabetic control group showed suppressed level of all biomarkers, while the treatments enhanced the expression of PFK, PPAR and GLUT2 gene in groups (3-4). This study showed that Nigella sativa oil modulated the expression of GLUT2, PPAR and PFK genes in streptozotocin-induced diabetic rats.
