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ABSTRACT
The study investigated the determination of the antimicrobial activity of brominated limonene on some pathogens. The orange peels were collected, shredded and extracted with distilled water using steam distillation method. Bromination was done to test for saturation while characterization was done by IR and GC-MS analysis. The results indicated that the limonene was saturated case it was decolorized by bromine compound. Major compound detected was 1717-octadecynoic acid (RT 15.469, 36.04%) a saturated fatty acid, N-(-2-Amino-2-oxoetyl-2-test-tetradecynamide (RT 20.081, 13.16%) a saturated fatty acid and 8 methyl-6-nonenoic acid (RT 10.84, 10 4%) an unsaturated fatty acid. From the FTIR result shown of the limonene was t 1633.60cm-1 (c=c) stretch alkene; 1456 cm-1 (C-H) bend alkyl group. The antimicrobial analysis revealed zone of inhibition at a concentration of 1:2ml (1 ml of distilled water in 2ml of the oil sample); 11mm (E coli) 0mm (Pseudomonas), 10mm (staph epididymis and 7mm (strept). A dose of independent activity was observed went compared to the standard control antibiotics (ciprofloxacin). This study reveals that orange peel extract (limonene) contains bioactive constituent with high antimicrobial activity against micro flora germs and could potentially poses rich medicinal values when subjected to further chemical and pharmacological studies.
