You have no items in your shopping cart.
ABSTRACT
Pre-eclampsia(PE) is a multisystem disorder which affects approximately 5-8% of all pregnant women worldwide with onset of symptoms in the late second or third trimester, most commonly after the 32nd week. Nearly one-tenth of all maternal deaths in Africa are associated with hypertensive diseases of pregnancy, a category that encompasses pre-eclampsia. Altered renal function is an important component of the patho-physiology of pre-eclampsia which could lead to acute renal failure, an important cause of morbidity and mortality. Although the cause of pre eclampsia is unknown, the manifestation of oxidative stress is a feature of pre-eclampsia and the main source of reactive oxygen species initiating the pathophysiological events appears to be the placenta. It is a serious complication of pregnancy with harmful effects on the immediate and long-term health of the mother and child which are avoidable with timely and effective care. One of such care is close monitoring of the renal status using biochemical indices such as plasma creatinine and urea, serum cystatin -c and β-2-microglobulin (Β2MG) and assessment of indices of oxidative stress which would no doubt improve their clinical outcome. However, because of the blind area in plasma creatinine, it is important that early indicators will improve diagnosis and clinical outcome of PE. It is therefore the aim of this study to assess the coexistence of renal insufficiency with cystatin -c and Β2MG and oxidative stress.
