ABSTRACT
Purpose: The aim of this study was to compare the binding strength OF IRVINGIA WOMBOLU (OGBONO GUM), COCOYAM STARCH, AND CORN STARCH AS BINDERS USING INTRAGRANULAR METHOD ON PARACETAMOL TABLETS.
Methods: Granules were prepared by using corn starch and cocoyam starch and Irvingia wombolu (Ogbono gum)mucilage respectively, The granules were characterized for physiochemical properties such as bulk density, tapped density, Carr’s index, angle of repose and Hauser'’s ratio, Thereafter, the granules were compressed at 27 units on the arbitrary scale load and tableting parameters such as hardness, friability, disintegration, drug dissolution studies and content uniformity were determined.
RESULT: All granules were compressible and free flowing. for 5% , 10% and 15% Corn starch mucilage granules the Carr’s index obtained is 9.38,8.07,and 9.68 respectively , Hauser's ratio 1.10, 1.09, 1.11 respectively, angle of repose 24.60, 23.10,22.80 respectively. For 5% , 10% and 15% cocoyam starch mucilage granules the Carr's index obtained is 9.7, 9.5 and 10.90 respectively, hauser’s ratio is 1.18 ,1.11 and 1.12 respectively, angle of repose is 23.01, 26.10 and 25 respectively. For 5% , 10% and 15% Ogbono gum ( Irvingia wombolu gum mucilage granules) the Carr's index obtained is 7.84 ,8.00, 7.55 respectively, hauser's ratio 1.09, 1.20, 1.08 respectively and angle of Repose 23.10,26.20 , 21.60 respectively .
The granules were compressible with tablet hardness for 5%, 10% and 15% Corn starch mucilage was found to be 6.67 ,7.33,and 7.83 respectively, friability 0.96, 0.90 and 0.87 respectively, disintegration time 8.65 ,9.22 and 10.52 respectively. For 5% , 10% and 15% cocoyam starch mucilage the table hardness obtained is 7.6, 7.33, 8.33 respectively, friability 1.0, 0.97, 0.95 respectively, disintegration time 5.17, 7.14, 8.14 respectively. For 5%, for 10% and 15% Ogbono gum (Irvingia wombolu gum mucilage) the tablet hardness obtained is 2.66, 4.2 and 5.10 respectively. Friability 3.12, 1.4 and 1.0 respectively disintegration time 7.44,8.22 and 11.34 respectively.
Conclusion: The paracetamol tablets were successfully formulated in this study using maize starch, cocoyam starch mucilage and irvingia wombolu gum as binders. The result shows that there were no significant difference in the binding strength of cocoyam starch and corn starch but there were significant difference in the binding strenght for 5% and 10% IRVINGIA WOMBOLU but not 15% irvingia wombolu. Hence cocoyam starch can be used as a substitute for maize starch as binders in the formulation of paracetamol tablets using the same concentration (5%, 10%, and 15%), as well as 15% irvingia wombolu. The release of paracetamol from the matrix tablet was affected by the concentration and type of binder as an increase in the concentration of the binder produced a reduction in the amount of drug released per time.
