ABSTRACT

Glomerular filtration rate accepted as the best overall measure of kidney function is known as the volume of fluid filtered from the renal (kidney) glomerular capillaries into the Bowman's capsule per unit time. It is a valuable marker for assessing kidney function and is particularly important for the detection, assessment and control of kidney disease (CKD). This study was carried out in 100 subjects to investigate a comparison of GFR in normotensive subjects with and without family history of hypertension between the ages of 18-30years with normal BMI of 18.5 to 25 kg/m2 comprising of 50 males and 50 females. Each sample comprises of 25 with and without family history of hypertension. To achieve the objectives of this study, a 24-hr urine is collected from each subject with subsequent blood sample collection. Serum creatinine level (Scr) and urine creatinine level were assessed with standard laboratory techniques. P>0.05 in males with and without family history of hypertension, in females with and without family history of hypertension and between males and females without family history of hypertension showing no significant difference in the mGFR/ Mcrcl. P<0.05 in males and females with family history of hypertension and between all males as compared to females showing significant difference in mGFR/ Mcrcl.