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Allium sativum (garlic) is a bulbous perennial herb that has found culinary and therapeutic applications among people of many cultures. Garlic and its supplements have exhibited numerous beneficial biological properties. However, several adverse effects, toxicity and interactions with different drugs and chemicals have also been reported about its therapeutic use (Tattelman, 2005). Besides the liver, the kidneys also involve in the metabolism and excretion of toxic compounds and, thus, are at high risk of damage. This study investigated the effect of garlic extract on the kidney function, electrolytes, urea, and creatinine after a 28-day period of enteral administration of graded doses of (125 mg/Kg, 250 mg/Kg, and 500 mg/Kg) garlic extract. Sodium, potassium and chloride were quantitatively determined in plasma by Ion Selective Electrodes (ISE) Method; bicarbonate was determined by Enzymatic Method, urea was determined by Urease Method, and creatinine was determined by Picric Acid Assay Method. Garlic extract did not significantly affect plasma concentrations of sodium, potassium, chloride, urea and creatinine. Therefore, garlic extract possibly does not affect kidney function in Wistar rats.
