You have no items in your shopping cart.
ABSTRACT
This study examines the effects of ethanol leaf extracts of Acalypha wilkesiana on plasma creatinine and urea levels in Wistar rats exposed to 1,2-Dimethylhydrazine. Thirty Wistar rats were divided into six groups: a normal control group, a tumor control group exposed to 1,2-Dimethylhydrazine, a group treated with 500 mg/kg of Xeloda, and three experimental groups treated with 200 mg/kg, 400 mg/kg, and 800 mg/kg of ethanol leaf extract of Acalypha wilkesiana. Plasma levels of creatinine and urea were measured to assess renal function. The results showed significant reductions in creatinine and urea levels in rats treated with Acalypha wilkesiana extracts compared to the tumor control group, with the highest efficacy observed at the 800 mg/kg dosage. These findings suggest that Acalypha wilkesiana possesses potential nephroprotective properties, offering a promising natural alternative for mitigating renal damage induced by 1,2-Dimethylhydrazine.
