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ABSTRACT
Pain is a distressing sensation arising from mechanical, thermal, and chemical stimulation. It has different qualities and can variously be described as stinging, burning, pricking, throbbing and throbbing etc. Pain is brought on by irritation of the nociceptors, which are pain receptors. Nociceptor nerve endings are autonomous nerve cells that react to painful stimuli. Datura stramonium is a plant which belong to the family of Solanaceae. They are found in tropical, subtropical, and even temperate areas, although it may grow in damp soils. Datura stramonium plant is use in traditional medicine to treat laxative, cough, pyrexia, and bronchial asthma. The analgesic drug pentazocine was used to evaluate the analgesic properties of the ethanol whole plant extract of Datura stramonium plant. The aim of the experiment was to evaluate analgesic properties on induced pains in rodents. Phytochemical analysis was carried out to determine the phytochemical present in the plant. Standard procedures were carried out using acetic acid, hot plate and tail flick method to induce pain. The result obtained from phytochemistry study revealed the presence of useful phytochemical with medicinal benefits. The analgesic study revealed a dose-dependent increase in pain latency and percentage inhibition in the mice indicating analgesic activity of the extract at dosage concentration of 60, and 180 mg/kg. It can be concluded the phytochemical compounds present in Datura stramonium can useful in pain management since possesses analgesic properties.
