ABSTRACT

Peptic ulcers, which are acid-induced lesions that affect the stomach and duodenum, are identified by denuded mucosa. The two principal factors of risk for peptic ulcer disease are H. pylori disease with non-steroidal anti-inflammatory drugs usage, however not everyone who has either disease or consumes NSAIDs will suffer peptic ulcer disease. Vernonia amygdalina belongs to the family, The plant Vernonia amygdalina is a little shrub with its leaves colouration of dark green and despite having become domesticated under certain parts of West Africa, while Carica papaya plant belongs to the family Caricaceae, an herb crop grown in tropics as well as subtropics areas that serves multiple functions. The plant has been employed for many years in traditional medicine to treat diabetics, digestive diseases, malaria, pneumonitis, pyrexia and vermifuge. The anti-ulcer drug omeprazole citrate was used to evaluate the anti- ulcer properties of the bi-herbal formulation of pawpaw and bitter leaves plant. To evaluate anti-ulcer properties by inducing in mice using Ethanol/HCL and Indomethacin induction for ulcer were employed. The anti-ulcer study revealed exhibited significant decreases in ulceration index on Ethanol/HCL and Indomethacin induced in mice indicating anti-ulcer activity of the extract at dosage concentration of 50, and 150 mg/kg. It can be concluded the phytochemical compounds present in bi-herbal formulation of pawpaw and bitter leaves possesses anti-ulcer properties.