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ABSTRACT
Peptic ulcer is a complicated and multifaceted condition characterized by gastric and duodenal ulcers. Despite medical advancements, managing peptic ulcers and associated complications continues to be difficult. A growing amount of research indicates that, among a diverse array of natural molecules, dietary polyphenols, with their varied biological modes of action, play a critical role in the management of gastric and duodenal ulcers. To this end, this study aimed to evaluate the gastroprotective, curative, and anti Helicobacter pylori properties of methanol extracts and fractions of Spondias mombin (stem bark) and Chasmanthera dependens (root). This study entailed preliminary evaluation of the proximate composition, phytochemical screening (qualitative and quantitative), antioxidant capacity, GC-MS and HPLC analysis of methanol extracts of both plants. A gastric lesions model induced by aspirin was used to evaluate the gastroprotective and curative effects of methanol extracts of the plants. Furthermore, the extracts were further fractionated using vacuum liquid chromatography with solvents of different polarities; in vitro Helicobacter pylori inhibitory potential of the extracts and fractions were assessed by determining the minimum inhibitory concentration and zone of inhibition. In addition, molecular docking studies of the phytochemicals identified from the most active fraction were carried out on H+/K+-ATPase and H2 receptors.
