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The widespread use of nanoparticles in various field can be attributed to the recent development of nanotechnology. Due to the impact of the nanoparticles a possible way to mitigate their effects has prompted a potential research. Thus, this study investigated the biochemical effects of vitamin C on aluminum oxide nanoparticles-induced toxicity in the testis and epididymis of male wistar rats. 30 male wister rats were administered intraperitoneally with Al2O3-NPs (70 mg/kg BW), and orally with different concentration of vitamin C (100 mg/kg, 200 mg/kg and 500mg/kg BW) every day for 7 days. Oxidative stress, sex hormones and sperm parameters were evaluated using standard techniques. The obtained results represented that exposure to Al2O3-NPs caused body weight increase. Sex hormones and antioxidant enzymes showed a significant increase or decrease, especially in Al2O3 and vitamin C treatment groups at different concentrations. In conclusion, the results obtained from this study the co-administration of vitamin C, particularly at 500mg/kg mitigated the adverse effects of Al2O3-NPs induced toxicity and enhanced the antioxidant defense system.
