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ABSTRACT Nanotechnology has gained a lot of attention across various industries. One of the most commonly used nanoparticles in nanotechnology is the zinc oxide nanoparticles (ZnO-NPs). ZnO-NPs are widely used in different industries due to their excellent performance and various application. However, there has been growing concerns about the toxic effect of ZnO-NPs on different organs including the kidney. In this study, we examined the effects of exposure to experimental grade ZnO-NPs co-administered with different concentration of vitamin C on the kidney of male wistar rats. Thirty (30) adult male wistar rats were placed in five groups of six animals each. The control group received 1ml of distilled water only while the experimental groups received 70mg/kg ZnO-NPs only, 70mg/kg ZnO-NPs plus 100mg/kg Vit C, 70mg/kg ZnO-NPs plus 200mg/kg Vit C and 70mg/kg ZnO-NPs plus 500mg/kg Vit C respectively for 7 days. Urea, creatinine and electrolyte (sodium, potassium, chloride, and bicarbonate) were assessed. To evaluate the oxidative stress levels in the kidney, malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) enzymes activity were measured. The findings from this study revealed that at a concentration of 100mg/kg vitamin C was able to reduce the toxic effect induced by ZnO-NPs on the biochemical parameters related to kidney function and oxidative stress. Additional studies should be conducted to explore the possible application of vitamin C supplementation as a defence against the harmful effects of ZnO-NPs on kidney function and oxidative stress parameters.
