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ABSTRACT
Malaria remains one of the most prevalent infectious diseases affecting mostly individuals in tropical regions of the world including Nigeria. Most of the country’s indigenous population relies on herbal medications for the management of Malaria. Thus, this study aimed at evaluating the antimalarial activity of a multi- herbal extract consisting of Enantia chlorantha, Nauclea latifolia, Azadirachta indica, Alstonia boonei, Sorghum bicolor, Anthocleista djalonensis and Cymbopogon citratus commonly used for the management of malaria in Benin city, Nigeria. The herbal decoction was assessed for antimalarial activity against chloroquine sensitive Plasmodium berghei (NK65) using the Peter’s 4-day suppressive test procedure. The multi-herbal extract showed a significant antimalarial activity (% parasitemia on days 4 and 10 were (4.42 ± 1.15) and (21.95 ± 1.45) respectively as compared to negative control group which was (9.09 ± 1.55) and (48.59 ± 2.51) on days 4 and 10 respectively. From Hematological study the multi-herbal extract treated group showed a significant increase (P <0.05) in lymphocyte, Granulocytes, and White blood cell levels. Thus, the extract may be decreasing parasite levels via immunomodulation. This perhaps may explain the use of the multi extract for malaria management.
