ABSTRACT
Ulcerative colitis (UC) is a chronic idiopathic inflammatory bowel disease (IBD) of the colon that causes a superficial mucosal inflammation in a continuous fashion extending from the rectum to the more proximal colon, in varying extents. This study was undertaken to assess the antioxidant activities of glutathione peroxidase and glutathione reductase in the colon liver and kidney and the effect of Annona muricata onacetic acid-induced ulcerative colitis rat model. The cause of ulcerative colitis include risk factors like genetics, age, diet and lifestyle, infections, and gut bacteria.
Rats were treated with three different doses of which include; Group 1 (control) were administered 1ml of distilled water, group 2 were administered 0.33g of Annona Muricata extractdissolve in 3ml of distilled water and group 3 were administered 5ml of distilled water for seven days prior to ulcerative colitis induction by 0.5ml of 4% acetic acid (AA). After a total of 11 days of administration, the rats were fasted for 24 hours and then sacrificed to extract the blood, colon, liver and kidney. In colon, kidney and liver samples, levels of glutathione peroxidase (GPx), glutathione reductase (GSH), and total protein were evaluated.
Annona muricata extract significantly (P < 0.05) prevented colonic ulceration and reduce inflammatory score. GPx,GSH, and total protein significantly reduced in the colon, kidney and liver samples. However, loss of body weight was not significantly affected by treatment with Annona muricata extract. This data suggest that Annona muricata extract has a potential antiulcerative effect.
