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ABSTRACT
Long Jack XXXL drug, derived from the Eurycoma longifolia (Tongkat Ali) plant, Horny goat weed, Fenugreek plant, Sinerian ginseng plant and Macca extract has gained attention for its purported benefits in male fertility enhancement. Despite its widespread use, limited research exists on its broader physiological effects. This study aimed to investigate the impact of Long Jack on digestive enzyme activities (amylase and lipase) and glucose levels in Wistar rats. Twenty five (25) adult Male Wistar rats were randomly assigned to control and experimental groups. The experimental groups including group 2 received (10mg/kg), group 3(20mg/kg), group 4(40mg/kg), and group 5(80mg/kg) long jack supplementation for 28 days, while the group 1(control) received feed and water. After 28 days, blood samples were collected for the assessment of amylase and lipase activities using standard enzymatic assays, along with glucose level measurements using spectrophotometric method. Data were compared using analysis of variance (ANOVA). Results indicate that Group 5 (107.4±2.205) exhibit significantly (p<0.05) higher mean amylase activities compared to the control group (94.8±2.518), while Group 2(104.4±2.657), group 3(103.8±2.213) and Group 4(104.2±3.153) show similar or slightly higher mean amylase activities. Serum lipase activity of group 2(79.8±2.577) and group 4(80.4±2.638) were significantly (P<0.05) increased compared to the control group (59.2±8.868), while group 3(77.0±3.894) and group 5(77.4±1.691) were similar to the control group. Similarly, glucose level of the group 2(126.8±6.815) was significantly (p<0.05) increased compared to the control group (100.2±5.851), while group 3(108.8±2.496), group 4(110.0±6.731) and group 5(115.3±0.8819) were not significantly different compare with control. The finding from the study indicates long jack supplementation may alter serum amylase and lipase activities and glucose level in a dose dependent manner.
