You have no items in your shopping cart.
ABSTRACT
Cassytha filiformis (Lauraceae), a widely distributed parasitic plant, contains several aporphine alkaloids and is often used in African folk medicine to treat cancer, African trypanosomiasis, and other diseases. Cassytha filiformis is a plant known for its various ethnomedical purposes in Nigeria. As a result of its anti-inflammatory quality, this study is essential. This study aims to determine the anti-inflammatory efficacy of Cassytha filiformis extracts in a rat model of arthritis induced by formaldehyde. Twenty- four albino rats were randomly distributed into seven groups of four rats each. Formaldehyde was inoculated through the sub-plantar region of the rats for 28 days from the day of immunization. Group 1 (control) was given as it were refined water, group 2 was given as it were 0.1ml of formaldehyde, which actuated joint pain, gather 3 was given 10mg/kg of Diclofenac (managed orally) the standard sedate for the treatment of joint pain and was moreover induced with 0.1ml of formaldehyde, 15 mg/kg, 30 mg/kg, 60mg/kg of C.filiformis extricates with 0.1ml of formaldehyde were given to gather 4,5, and 6 individually. Blood test (2 ml) was collected from the albino rat person rodent through the retro-orbital depression beneath the impact of anesthesia, centrifuged at 3000 rpm at room temperature, and inspected for Catalase (CAT) and Serum Superoxide Dismutase fiery exercises. Catalase comes about appeared that the cruel values expanded from 0.33±0.03 31 (Umol/L) to 0.66±0.03 (Umol/L) in formaldehyde gather (gather 2) and the Group with as it were 10mg/kg Diclofenac treatment (gather 3) separately. SOD mean value ranges from 0.709±5.31(U/g tissue) in the 0.1mg/kg formaldehyde-only group (Group 2) to 66.87±2.92 (U/g tissue) in the 10mg/kg Diclofenac group (Group 3). In conclusion, it was observed that the standard drug (diclofenac) is a good treatment for arthritis but not better than Cassytha filiformis extract. The extract at 60mg/kg has a better effect in healing formalin-induced arthritis than the standard drug (Diclofenac).
