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ABSTRACT
One of the hallmarks of cancer cells is their ability to avoid the process of apoptotic for normal cells. They ignore signals that would regulate cell growth and division. Traditionally some plants are used as herbs to treat certain malignant tumors. Spondias mombin is an angiosperm plant that belongs to the Anacardiaceae family. The plant is believed to possess some phytochemicals which confers anticancer properties. The aim of this study is to evaluate the apoptotic effects of Spondias mombin stem bark extracts on dimethylhydrazine (DMH) induced colon cancer in Wistar rats. A total of thirty-five (35) male Wistar rats were used for this experiment. They were grouped into five groups; Group 1 (normal control), Group 2 (DMH only- negative control), Group 3 (DMH + Xeloda - Standard Drug), Group 4 (DMH + 500mg/kg bwt crude hydroethanol extracts), Group 5 (DMH + 500mg bwt crude ethanol extracts). The results should high expression of proapoptotic genes which are; Caspase-3 genes, B cell lymphoma 2 genes, and p53 genes and there was down regulation of antiapoptotic genes - Bcl like protein 4 genes. Therefore, it was concluded that Spondias mombin has positive apoptotic and anticancer properties.
