You have no items in your shopping cart.
This study aims to prove or disprove the hypothesis that consuming meat boiled with paracetamol increases the risk of, or directly results in, renal and/or hepatic failure. This was accomplished by assaying for glutathione peroxidase activity as well as superoxide dismutase, Malone dialdehyde, and catalase activity after inducing subchronic toxicity for 28 days. A total of 22.4 kg (wet weight) of meat was mixed with feed in varying proportions during the process of diet formulation. The meat was boiled with 3g of paracetamol (six 500mg tablets) per 1 liter of water. 40 rats were shared into groups containing 5 rats each. Group 1 (control) were administered normal feed, group 2 (Uncontaminated) were administered feed mixed with meat boiled with only water while groups 3, 4 and 5 (subdivided into; acetaminophen and potash) were administered feed mixed in ratios; 9:1, 8:2, 7:3 diet to feed composition of meat in grams. The rats were starved for 24 hours and then anaesthetized individually with chloroform before harvesting. 1g of both organs (liver and kidney) from each group, was homogenized in 10ml normal saline after which centrifugation took place at a speed of 20000g for 15 minutes, the supernatant separated into containers, sealed and refrigerated pending usage. This research focuses on the groups of rats fed with meat boiled with acetaminophen. The results showed no significant changes in the activities of SOD, CAT, GPx excluding those of acetaminophen 30% and acetaminophen 20% for liver and kidney respectively. This further goes to show no resulting liver or kidney damage from consumption of meat boiled with acetaminophen over
