ABSTRACT
Background: Tetrapleura tetraptera is a medicinal plant native to Africa with strong traditional and Cultural significance. It is a tree species in the family of Fabaceae( Leguminosae). T. tetraptera is commonly known as Gum tree (English), Oshosho, Obogolo
(Igbo), Aridan, Aid an (Yoruba), Eseyeseye, Ighimiaka (Edo). It is commonly used to prepare herbal concoctions and combinations for the treatment of diseases such postpartum haemorrhage, diabetes, and uterine fibroid, among others. At the Forest Research Institute of
Nigeria (FRIN), in Osun state, the plant (T. tetraptera) was procured and authenticated
Aim: The purpose of this study is to ascertain if the ethanol root extract of T. tetraptera plant
has anti-fibroid properties against monosodium glutamate (MSG)-induced fibroid in Sprague- Dawley rats.
Method: The Soxhlet extraction method was used to extract the dried, powdered root of T. tetraptera. To identify the phytochemical elements in the root extract, a phytochemical screening procedure was carried out. Lorke's approach was used to conduct investigations on both acute and delayed toxicity. Studies on the prevention and treatment of 800 mg/kg MSG-induced uterine leiomyoma in Sprague-dawley rats were carried out utilizing 100, 200, and 400 mg/kg dosages of T. tetraptera root extract (measured total plasma cholesterol, plasma protein, and plasma estradiol). The uterus and blood samples underwent histology examinations and biochemical tests, respectively.
Result: Following extraction, 29.25% of the extract from Tetrapleura tetraptera's root was yielded. When the rats were given MSG, their levels of cholesterol and estradiol (which indicates hyperplasia) increased significantly (P < 0.05–0.01) in the preventive therapy by 57.41% and 90.00%, respectively, and by 54.00% and 109.00%, respectively, in the curative treatment. The oral dosage that proved deadly was higher than 5000 mg/kg.
Conclusion: The ethanol root extract of T. tetraptera reduced MSG-induced uterine hyperplasia, making it effective as an anti-fibroid medication.
