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ABSTRACT
The work presented in this thesis involves the scientific investigation of the traditional uses of the leaves of Vernonia amygdalina (Asteraceae) as an anthelmintic, antimalarial and antiinflammatory agent. It also describes the isolation, phytochemical properties and characterization of the active principles from the Vernonia amygdalina. The 70% ethanolic extracts of the leaves were tested for anti-bacterial activities. The Antibacterial evaluation of extracts at concentrations of 10 mg/ ml was done using the agar well diffusion and micro-dilution assays. Three organisms; Pseudomonas aeruginosa, Escherichia coli, Staphlococcus aureus were used. The aqueous extract of the leaves were tested for antibacterial activities. The results of these studies have demonstrated that extracts of the leaves of Vernonia amygdalina possess anti-inflammatory activity and also display antioxidant and antimicrobial activities. These findings provide scientific justification for the use of leaves of Vernonia amygdalina in various traditional medicines, for the treatment of inflammatory and infectious conditions.
