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ABSTRACT
Garcinia kola has been referred to as a "wonder plant" as every part is of medicinal importance. Inflammation is a pathological effect in the tissue that triggers local plasmatic blood cell or fluid increase. This study evaluates the effect of an aqueous extract of G. kola seed on egg albumin-induced inflammation in an animal model.. The aqueous extract at 25, 50 and 100 mg/kg and reference drug (100 mg/kg acetylsalicylic acid) were orally administrated for 14 days to investigate the anti-inflammatory property. The paw volume was recorded using a Vernier calliper at 0, 30, 60, 90 and 120 hours to determine its half-life and duration of action in which the effect of the extract elapses. More so, the paws' weight was recorded across the groups. The results showed a significant decrease in the paw volume across the treatment groups compared to the control group. Specifically, at 50 mg/kg, the extract showed an inhibitory potential against the inflamed paw of the rats when compared with the untreated control. There was a significant reduction in paw weight across the treatment groups compared with the control. Also, at 50 mg/kg, it showed a deep decrease in weight, similar to the reference group. In conclusion, G. kola aqueous extract's effect showed anti-inflammatory properties, which validated its folklore uses.
