ANTI-HYPERLIPIDEMIC AND BIOCHEMICAL EFFECT OF ACTIVATEDCHARCOAL FROM Terminalia catappa ON CHOLESTEROL INDUCED WISTAR RATS

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ABSTRACT

Cardiovascular disease and artherosclerosis are risk factors of hypercholesterolemia. This study shows terminalia catappa activated charcoal antihyperlipidemic effect on hypercholesterolemia. In this study the stem bark of terminalia catappa into activated charcoal for the treatment of high levels of hypercholesterol in wistar rats. Terminalia catappa leafs were gotten and subjected to the air tight thermofischer muffle furnace at 1450°C in oxygen absence for an hour to make the stem bark to become a highly porous charcoal with a large surface area. In this study, 12rats were divided into 4 groups of 3 rats each. All the groups except group 1 (control) were induced with 5% cholesterol. The rats in group 3 and 4 with hypercholesterolemia were given activated charcoal of 200mg and 10mg of Atorvastatin while those of group 2 were left untreated. Through results gotten from GC-MS. There was reduction in the potassium and sodium levels.

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